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Mechanism of Action and Pharmacokinetics GLP-1 RAs enhance glucose-dependent insulin secretion, suppress glucagon release, delay gastric emptying, and promote satiety

162,163,164 Exa-cel (Casgevy) was approved in November 2023 as the first gene-editing therapeutic drug based on the CRISPR/Cas9 system for treating sickle cell disease (SCD) and transfusion-dependent -thalassemia (TDT)

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Women with contraindications or those preferring non-hormonal options may benefit from paroxetine, fezolinetant, or off-label SSRIs/SNRIs

Hruby ontving voor zijn werk in dit gebied een reeks academische onderscheidingen