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Six trials totaling roughly 900 participants are summarized in Stier et al

Contraindications and special populations : Berberine should be avoided during pregnancy and breastfeeding due to insufficient safety data

While many of these mechanisms are just hypothesized from limited clinical trials performed on animal models, more extrapolation is required to know the exact pharmacodynamics of DSIP

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Honestly, our team has observed that for systemic effects, the exact timing is less critical than unwavering consistency