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Wyss & Kaddurah-Daouk ( Reference Wyss and Kaddurah-Daouk 17 ) reported that this process utilises more SAM than all other methyltransferase reactions combined

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In experiments using melatonin, either melatonin (10mg/kg, Sigma) or an equivalent volume of DMSO (Sigma) was intraperitoneally injected each day for three days at 17:00, immediately after intranasal challenges had been performed