Glucagon biology can be metabolically useful in the right context, but it is not as straightforward as GLP-1 appetite suppression
Because IV infusions deliver nutrients directly into the bloodstream, reactions can sometimes manifest faster than with intramuscular injections
Bridgewater, NJ: Sanofi-aventis U.S.;2019
It was impressive to see that every dose of retatrutide resulted in clinically meaningful weight reduction for nearly all participants, and people with severe obesity on the highest dose lost on average 30% of their body weight over two years, said Ania Jastreboff, a medicine and pediatrics professor at the Yale School of Medicine who led the study, in a statement accompanying the press release
doi: 10.1111/jgh.14129 107
Tirzepatide works differently from older GLP-1 medications by targeting two hormone pathways simultaneously