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Empagliflozin resulted in reductions in incident or worsening nephropathy, a doubling of serum creatinine levels and renal replacement therapy in a pre-specified analysis of the EMPA-REG trial.52 Likewise, the results of the CANVAS study showed a possible benefit of canagliflozin in terms of the progression of albuminuria and a composite endpoint that included a sustained 40% reduction in GFR, the need for renal replacement therapy, or death due to renal causes.50 In contrast to the results previously reported with liraglutide, those afforded by the SGLT2 inhibitors included robust targets
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Alcohol can compound these risks by contributing to dehydration, arrhythmia susceptibility, and hemodynamic instability
Once approved by the FDA, coverage for retatrutide may depend on: Medicare policies Commercial insurance plans Obesity diagnosis criteria Type 2 diabetes status Employer-sponsored coverage for weight loss medications Some insurers currently do not fully cover weight loss drugs unless patients meet strict medical requirements
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