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previous serious hypersensitivity to semaglutide or GLP-1 agonists

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Some physicians use compounded options to "micro-dose," allowing a patient to take a dose smaller than the standard 0.25mg if their weight loss is occurring too rapidly

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T., & Yanik, K

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Injectable research tells a different part of the story

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These studies demonstrate that localized GLP-1R activation enhances cholesterol efflux, reduces plaque lipid burden, and suppresses inflammatory gene expression even at doses too low to alter systemic metabolic parameters

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