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OPG is a soluble circulating decoy receptor for RANKL and is secreted by cells and binds to the extracellular structural domain of RANKL, preventing RANKL from osteoclast binding (Honma et al., 2013)

Learn more about what can cause a B12 deficiency and how this can present

doi: 10.1016/j.tjnut.2023.05.012 23 MathewsDMJohnsonNPSimRGOSullivanSPeartJMHofmanPL

It also has antioxidant effects, reducing the harmful effects of reactive oxygen species and protecting DNA from damage

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Additional contraceptive methods are advised for 4 weeks after starting Mounjaro and after each dose increase