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American Journal Of Physiology

So there was a couple papers talking about increase included found in the brain

Cobalamin deficiency results in the decrease of this conversion, resulting in high plasma levels of homocysteine, which is associated with a higher risk of cerebrovascular disease, depression, dementia, cellular stress, and apoptosis (25, 27, 64, 70)

These metabolic switches should influence astrocyte functions such as energy supply, redox balance, and inflammatory responses, thereby contributing to disease progression (Figure 4)

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