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Quick Answer: Metformin does not directly cause peripheral neuropathy, but long-term use can interfere with vitamin B12 absorption, potentially leading to deficiency that may cause or worsen neuropathic symptoms
First, the association comes from groups of patients, largely hospital populations already unwell enough to have blood taken
Both Eli Lilly and Novo Nordisk are advancing oral GLP-1 therapies as well
In other words, levocarnitine itself is not the problem
Glucagon-like peptide-1 as predictor of body mass index and dentate gyrus neurogenesis: neuroplasticity and the metabolic milieu