Unlike Semaglutide (single GLP-1 agonist) or Tirzepatide (dual GIP/GLP-1 agonist), Retatrutide activates three distinct metabolic hormone receptors simultaneously
Staying well-hydrated and maintaining a consistent routine can help manage this side effect
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Meet our doctors Last reviewed: 02 Jun 2026 Sources Saxenda 6 mg/mL solution for injection in pre-filled pen, EMC [accessed 26 January 2026] Wegovy 1 mg, FlexTouch solution for injection in pre-filled pen, EMC [accessed 26 January 2026] Accessing Wegovy for weight loss: Everything you need to know, Gov
Clinicians should set realistic expectations during the informed consent process, emphasizing that digestive side effects are expected but usually transient and often improve with continued treatment