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further, direct mechanisms of gut microbiotahormone signals on pancreatic lipase secretion for host metabolic manipulation need to be studied to provide novel insights into the interaction between gut microbiota and lipid absorption

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Dose escalation schedule used in retatrutide clinical trials (Phase 2 and Phase 3 TRIUMPH program) Dose Escalation Schedule (from Clinical Trials) In both Phase 2 and Phase 3 trials, retatrutide was administered as a once-weekly subcutaneous injection with gradual dose escalation: Source: NEJM Phase 2 protocol

doi: 10.1002/ajmg.a.60688 238 BoerHHollandAWhittingtonJButlerJWebbTClarkeD