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Consequently, it is essential to prioritize shared decision-making and individualized risk-benefit assessments for prescribing GLP-1 RAs, while avoiding misuse with off-label indications
However, this wasnt a breakthrough in pharmaceutical innovationit was a clever exploitation of a temporary anomaly
J Clin Endocrinol Metab 108(4):920930 ElSayed NA, Aleppo G, Aroda VR, Bannuru RR, Brown FM, Bruemmer D et al (2023) 2 Classification and diagnosis of diabetes: standards of care in diabetes2023
In simple terms, semaglutide qualifies when a licensed healthcare provider prescribes it to treat a diagnosed medical condition
This poses a large obstacle in the investigation of PPI use as most studies are forced to rely on retrospective studies or non-human models, which further increase the number of variables leading to an unclear illustration of the effect of PPIs
19 This effect likely contributes to the decreased risk of stroke in T2D patients receiving treatment with certain GLP-1RAs
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