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Further evidence will be necessary before we can see the complete picture, but they show promise as, at the minimum, an adjunct to current therapy, says Esposito

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For more complex drugs like Mounjaro, especially ones that are injected, this whole process can take months or even a few years after the patents start to expire

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As such, glomerular lesions occur which include glomerular basement membrane thickening, podocyte effacement and loss, mesangial expansion, epithelialmesenchymal transition EMT and fibrosis, collagen deposition, damage to the capillary architecture and an influx of inflammatory cells including macrophages