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Unlike oral supplements, injections allow the vitamin to be absorbed directly into the bloodstream, making it available to the body quickly

[7] implicated 4-OH-E 2 in the induction of estrogen-responsive genes, a response that exhibited partial or no abrogation by coadministration with an antiestrogen, providing evidence for the ability of 4-OH-E 2 to carry out genetic upregulation via a pathway independent of ER signalling

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