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The only clinically relevant difference between treatments was the higher frequency of gastrointestinal related adverse events with IcoSema versus icodec or semaglutide alone, which can be mitigated by appropriate dosing recommendations for IcoSema, as discussed above

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GLP-1RAs have demonstrated beneficial actions in the setting of acute myocardial infarction 20,103110 , heart failure with reduced ejection fraction (HFrEF) in both lean and obese 111 , in atherosclerosis 112114 , and peripheral artery disease 115,116

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