Caruso U, Leone L Cravotto E Nava D
However: Larger meta-analyses show no significant increase in risk after adjusting for confounders [25] Incidence appears similar to other diabetes therapies [25] Much of the observed signal likely reflects: Baseline risk (obesity, T2DM) Secondary gallstone disease In summary, pancreatitis in GLP-1 users is a rare and possible complication, but current evidence does not support a substantial increase in risk directly related to GLP-1 agents
Incretin-based GLP-1 therapies have additional effects, e.g., the reduction of glucagon, the slow down of gastric emptying, and inducing the sense of satiety
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