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All TPP-dependent enzymes contain a highly similar TPP-binding domain and its lack in the TKTL1 encoded protein strongly suggests that it is unlikely that TKTL1 is a TPP-dependent protein capable of catalyzing the transketolase reaction

Presumed it was a side affect of having such heavy doses all at once and hoping they will go soon

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doi: 10.1007/s004150050386 47 Li Hi ShingSChipikaRHFineganEMurrayDHardimanOBedeP

Reactive Oxygen Species (ROS) , sometimes referred to as free radicals or collectively oxidative stress, are unstable molecules produced by normal body functions and exposure to external stressors and toxins

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