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13 In the SURPASS-4 trial (phase III), participants taking tirzepatide showed a much lower occurrence of composite kidney endpoint (time to first occurrence of eGFR decline of at least 40% from baseline, end-stage kidney disease, death due to kidney failure, or new onset albuminuria) compared with those who received insulin glargine (HR 0.58)

Peroxiredoxin (Prx) 3, a cysteine-dependent peroxidase enzyme, is also present in the mitochondria, whereas Prx5 can also be found in the cytosol, in peroxisomes, and in the nucleus [28]

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For Empagliflozin 21 pregnancies were reported of which 8 listed the corresponding pregnancy outcomes: 2 spontaneous abortions, 1 elective termination, 1 ectopic pregnancy, 3 healthy infants without congenital anomaly, 1 premature infant

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