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They require titration, management of side effects, and ongoing monitoring

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It does this by decreasing the production of lipase in the stomach and pancreas, resulting in weight loss ( One study in 40 women with obesity also found that long-term use of orlistat increased levels of certain hormones that suppress hunger and appetite ( However, other studies have found that orlistat could decrease these hormones and instead speed up the emptying of the stomach ( Aside from potentially affecting hormone levels, other common side effects of lipase inhibitors include diarrhea, stomach pain, and fat in the stools ( summary Enzyme inhibitors block the activity of digestive enzymes, which could promote weight loss and fat loss

The absence of a gallbladder changes bile storage and release, potentially affecting medication absorption and digestive tolerance