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Splitting ALA into smaller doses may help reduce gastrointestinal side effects, especially at higher intakes.43 Taking ALA with food can also improve tolerability though some studies suggest it may slightly reduce absorption.13 44 That tradeoff may be worth it for users sensitive to GI effects, particularly when taking ALA long-term

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A diverse, balanced gut flora is associated with optimal SCFA production, which may in turn support L-cell function

2024;doi:10.1016/j.xops.2024.100547