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Introduction Suppose youve seen the recent addition of semaglutide (brand name Wegovy) to the list of FDA-approved treatments for weight management
A combination of strength training and cardiovascular exercise works best
These medications have demonstrated substantial benefits in glycemic control, weight reduction, and cardiovascular outcomes, contributing to their rapid uptake in clinical practice ( 1 , 3 )
The medication is FDA-approved for adults with obesity or those who are overweight with weight-related health conditions, making it an effective option for individuals struggling to lose weight through traditional methods alone
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Key Takeaways Retatrutide targets three hormones (GLP-1, GIP, glucagon), tirzepatide targets two (GLP-1, GIP), and semaglutide targets one (GLP-1) At 68 weeks, retatrutide achieved 28.7% average weight loss, tirzepatide approximately 22%, and semaglutide around 17% on the highest doses Side effects are similar across all three medications, mainly digestive issues like nausea and diarrhoea Retatrutide is not yet approved and won't be available until mid-2026 at the earliest Retatrutide is not yet approved and is not currently available in the UK Tirzepatide (Mounjaro) and semaglutide (Wegovy) are both available now in the UK through NHS or private providers By entering I agree to the Terms and Conditions
