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Anecdotal reports of hair loss are often attributable to confounding factors [5]

Studies frequently emphasise its influence on the VEGFR2 pathway and its stability in harsh tissue environments such as the gut

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O'Neil, PhD commented that the results from the Surmount trial show that regardless of BMI, regardless of age, regardless of number of obesity-related health complications, there was a clear dose-related weight loss that was pretty consistent across groups. He also added that the absolute levels of weight loss are higher than we've seen thus far with [anti-obesity] medications and that tirzepatide is a notch up from Semaglutide. The SURMOUNT-1 trial compared the efficacy and safety of tirzepatide 5, 10, and 15 mg subcutaneous once-weekly to placebo, as an adjunct to a reduced-calorie diet and increased physical activity

Genetic testing also informs expectations around side-effect timing and intensity