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Because dosage affects metabolism and appetite regulation, all changes must be supervised by a medical provider to ensure safe, effective treatment

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Four (4) events of hypoglycemia defined as a plasma glucose less than 54 mg/dL occurred in 2 (1.6%) of 125 SAXENDA-treated patients and 1 event occurred in 1 (0.8%) of 126 placebo-treated patients

This effect has been confirmed in cell lines and rodent models, though direct human pharmacokinetic data comparing plasma amphetamine levels with and without zinc supplementation remain sparse

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They are also showing up in the restaurant industry