doi: 10.1016/j.cmet.2024.10.016 94 XuZWenjingYWentaoCYanbingZQiuyunNValencakTGet al
Given the copper pathways implicated, users with pre-existing copper overload, Wilson disease, or severe liver disease may be at increased risk and should avoid use
In vitro experiments have shown that GSH deficiency induced by either the siRNA approach or pharmacological inhibition of the GCL rate-limiting enzyme decreases GSH biosynthesis and escalates oxidative stress in cultured hepatocytes
LONP1 downregulation with ageing contributes to osteoarthritis via mitochondrial dysfunction
It has been proposed that epithelial and mesenchymal cells survival relies on the signaling provided by integrins attached to a rigid surface and that culturing them in 3D gels leads to cell death by preventing attachment to a rigid surface [26]
DOI.org (Crossref) , Greenfield, Jerry R., et al