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Study-related adverse events In a 26-week, open-label study in adult patients (N=665) comparing Victoza 1.2 mg, Victoza 1.8 mg, and sitagliptin 100 mg, all in combination with metformin, the adverse reactions reported in 5% of patients treated with Victoza were nausea (23.9% vs 4.6%), headache (10.3% vs 10.0%), diarrhea (9.3% vs 4.6%), and vomiting (8.7% vs 4.1%)

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Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy

doi: 10.3389/fpsyg.2022.907637