As an additional analysis, changes in weight and HbA1c, including the composite weight and HbA1c outcomes, were compared over the follow-up period in the following patient subgroups: persistentpatients who were persistent to the index therapy (defined as patients with 60 days gap in supply)
Second, different chemical structures, pharmacological profiles, and modes of action of these GLP-1RA are available, and although the differences are subtle, head-to-head cardiovascular outcomes trials for this class of drugs are not available, which limits the ability to detect differences in outcomes between GLP-1 agonists of different structures or potencies and to rule out whether they affect treatment outcomes
Campayo A, De Jonge P, Roy JF, Saz P, De la Cmara C, Quintanilla MA, et al
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