The mechanisms potentially contributing to cardiovascular protection may include effects on weight, glycemic control, blood pressure, and possibly direct effects on vascular inflammation and lipid metabolism, though these mechanisms remain under investigation
Interrogates dual GPCR signaling
Guidelines provided by KDIGO similarly recommend SGLT2i for people with an eGFR of 30 ml/min/1.73 m 2 due to the vascular and renal benefit, despite its modest effect on glucose control [2]
A close look at CivicSciences ongoing data collection of QSRs shows that GLP-1 users are more likely to frequent some restaurants more than others
The combination is extrapolated from separate studies of each compound individually
However, from a QSR standpoint, the more important numbers might be that 18% stop use after just three months, and 31% discontinue use after six months 10