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Semaglutide mimics a hormone your gut produces after eating - it tells your brain you're full, slows how quickly your stomach empties, and improves how your body manages blood sugar
increased scrutiny from regulators
The more recent SURMOUNT-5 trial directly compared tirzepatide to semaglutide and found tirzepatide superior , with 20.2% weight loss versus 13.7% for semaglutide at 72 weeks
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TABLE 2 Summary of methods used to identify GLP-1R expressing cells within the gastrointestinal tract
The first is protein intake - specifically, whether you're consuming enough per meal and per day to support muscle protein synthesis while you're in a caloric deficit
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