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The brain is particularly susceptible to oxidative stress due to its high oxygen consumption, lipid content, and relatively low levels of antioxidant enzymes compared to other tissues

One study showed that LSH lower the concentration of lipid ROS and iron by interacting with WDR76, activating lipid metabolic genes, including SCD1 and FADS2, which inhibit the accumulation of lipid ROS and intracellular iron (Jiang et al., 2017a)

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