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4,207,208 The resultant neuronal hyperexcitability and microglial activation lead to chronic neuropathic pain

Accordingly, GSTs are generally strongly induced in response to biotic and abiotic stresses, which coincides with cellular roles in primary and secondary metabolisms, in stress tolerance or cell signaling, and in xenobiotic detoxification by acting as phase II enzymes (Wiegand et al., 1986

Cagrilintides activity within this region influences downstream hypothalamic signaling pathways

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