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A 2023 review concluded that L-carnitine supplementation may reduce fasting blood sugar and hemoglobin A1c, while also improving insulin sensitivity in people with diabetes, overweight, or obesity
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Instead, they create metabolic conditions that support better adherence and energy levels in patients committed to structured diet and activity plans
According to a Cochrane analysis, although some beneficial effects on pain and improvement in vibration perception threshold have been reported, no conclusive evidence has been found to support a significant reduction in pain after 612 months of treatment with acetyl-L-carnitine in patients with DPN [111]
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