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While there are big reasons for this, like well-publicized research about the impact alcohol has on health and a general decline in social activities among Gen Z, one connection thats only just getting some attention is that between GLP-1 medications, like semaglutide and tirzepatide, and alcohol use

Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response

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GLP-1 RAs induce an increase in heart rate (HR), which, theoretically, represents a safety concern, as this is considered to be associated with higher cardiovascular risk [13, 14]

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"Unfortunately, these drugs, like all peptide-based medications have to be administered by subcutaneous injections due to their chemical structure, and cannot be taken orally as tablets," says Prof