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[40] [41] Mechanism of action [edit] Tirzepatide has a greater affinity to GIP receptors than to GLP-1 receptors, and this dual agonist behavior has been shown to produce greater reductions of hyperglycemia compared to a selective GLP-1 receptor agonist

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The structure enables a comparison of the only two inactive peptide-free class B GPCR structures and increases our structural understanding of their activation pathways, which may be helpful in the design of novel ligands, thereby enabling new avenues for drug discovery on therapeutically important class B GPCRs

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Further, domain specific mutation effects of GNE were observed on mitochondrial dependent cell apoptosis 16