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Lyoprotectants prevent bilayer damage, leakage of encapsulated materials and vesicle aggregation
A primary and a supplementary estimand were prespecified: the treatment regimen estimand reflected the treatment effect in the presence of predefined intercurrent events, including intake of obesity management medications prohibited by the protocol and early treatment discontinuation, and the efficacy estimand reflected the treatment effect as if all trial participants had adhered to treatment and had not received any obesity management medications prohibited by the protocol
The overall discontinuation rate due to side effects was 7%
MOTS-c + Wolverine Blend: High compatibility, recommended
If you have plateaued at lower doses, completing your titration should be the first intervention
Diabetes 13 , 1179551420912972 (2020)
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