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reversing these effects requires sustained antioxidant support rather than a single dose

165 APOE is a lipid and cholesterol transporter with numerous CNS-related functions, including regulation of microglial and astrocytic functions, 100,166,167 cerebrovascular integrity, 168 BBB integrity, 169,170 myelin dynamics, 166,171 and neuronal network activity

Future research must prioritize the identification of these core genetic and environmental signatures and elucidate how they contribute to the transition from precancerous conditions to invasive cancer

doi: 10.3233/nre-240027, 19

When those effects are removed, the metabolic rebound is proportionally larger