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augment insulin sensitivity via glycogen turnover Yoga twice weekly : autonomic balance and mobility Optional second 10-minute walk to stack metabolic benefits Mechanism: Muscle contractions translocate GLUT4 independent of insulin, increasing glucose uptake and lowering 24-hour insulin exposure

Tham et al, 2015])

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227 Determining whether GLP-1 has direct/indirect effects on islet alpha-cells and what receptor(s) mediate these actions requires further investigation

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This modified version of OXM safely improved body weight and lipid metabolism when compared with a long-acting GLP-1R agonist in DIO mice [79]