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The safety profile of semaglutide 2.4 mg in STEP 5 was consistent with that in other STEP program trials 6,7,9,16,23 , and with the GLP-1 receptor agonist class in general 28
Most patients notice early weight loss during the first month at the 2.5 mg initiation dose, with more substantial fat loss occurring between months 3 and 9 of therapy
Levinson W
thus, there appeared to be an additional direct psychological effect of GLP-1 receptor agonists, rather than the weight loss per se
It also indirectly reduces oxidative stress by regenerating vitamins C and E and acting as a cofactor for other antioxidants in the body
In addition, peptide therapy in general may lead to side effects related to the route of administration, which, in the case of ipamorelin, is subcutaneous injection
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