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Nearly 12 percent of Americans, roughly 40 million, have used a GLP-1 for weight loss, including about one-fifth of women ages 50 to 64, a recent RAND report finds

It's a common synthetic antioxidant that's used as a preservative

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For example, in the EMPA-REG OUTCOME trial, patients randomized to receive empagliflozin experienced a significant reduction in cardiovascular death, all-cause mortality, and hospitalization for heart failure compared to placebo despite only modest differences in HbA1c between groups [22]

At the same time, a 2024 systematic review concluded that there is limited and insufficient high-quality evidence to determine the optimal timing of arthroplasty after bariatric surgery (de Ree et al., 2024)