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490 Excessive inhibition of Nrf2 may not improve DOX-induced cardiomyopathy due to insufficient promotion of antioxidant gene expression, while its overactivation increases the breakdown of heme and ferrous iron levels in the HO-1-catalyzed manner, promoting ferroptosis

Compounded hydroquinone tretinoin formulations: These come pre-mixed into a single product, which makes them more convenient

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NAC may reduce the risk of heart disease by minimizing oxidative damage to cardiac tissues

While the latter might be relevant to conditions such as pathogen challenge, current concepts suggest that the relatively low antioxidant complement of the apoplast enables this compartment to exist in a more oxidized state compared to the cell interior (Pignocchi et al