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Inflammation also alters transcellular transport mechanisms

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A maximal deletion of Gclc was required to cause weight loss and reduction in survival in mice, as heterozygous deletion did not cause mice to lose weight (Fig

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Combined with adequate protein intake (widely recommended at 1.2-1.6g per kg of body weight during GLP-1 protocols) and resistance training, the higher dose ranges may actually preserve lean mass better than lower doses, because the energy deficit is being met predominantly through fat oxidation rather than muscle catabolism

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