Inadequate repair or continuous damage may cause double-strand breaks in the DNA, though DNA strands can be produced in various ways (46)
Improving action of antioxidant as Vitamin C, Vitamin E, Coenzyme Q, Glutathione
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Notably, Lpin1 induction is dependent on elevated ROS and ATM levels, and this process is inhibited by the N-acetyl cysteine antioxidant (66)
However, factors such as stress, toxins, aging, and certain diseases can lower glutathione levels in the body
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