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A net positive

Combination therapies Besides the combination therapies described above, in patients with bridging fibrosis and cirrhosis, combining cilofexor (ACC inhibitor) and firsocostat (FXR agonist) for 48 weeks was well tolerated, showed beneficial effects on MASH disease parameters, and might improve fibrosis

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International Journal of Molecular Sciences, 24 (3), 2370

Additional substitutions throughout the sequence optimize receptor binding geometry and resistance to proteolytic degradation

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