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For broader stacking-safety context see the PepPal side-effects guide

Some reactions and properties of nitro radical-anions important in biology and medicine

Reported side effects Mild headache or fatigue typically transient during initial use Mild gastrointestinal discomfort reported in some oral formulation users Sleep disruption or irritability potential sign of overstimulation Theoretical safety concerns Critical note: Because Dihexa activates the HGF/c-Met pathway which promotes cellular growth and repair there is a theoretical concern that it could potentially stimulate unwanted cell proliferation in individuals with active cancer or high cancer risk

doi: 10.1016/j.jep.2024.119256 32 LiuXWuHRenZWangYYangGCongHet al

Liver microsomal biotransformation of nitro-aryl drugs: mechanism for potential oxidative stress induction