This results in: Reduced appetite and caloric intake Enhanced satiety between meals Elevated metabolic tone and mental energy Tesofensine acts centrally to suppress appetite by increasing monoaminergic neurotransmitter levels in the hypothalamus. Astrup, The Lancet What makes Tesofensine unique isnt just its effect on hunger it also elevates dopamine , which may improve mood, motivation, and drive during a cut
A B12 deficiency can result in fatigue, weakness, memory problems, and even more severe health issues such as anaemia or neurological damage if left untreated
doi:10.1016/S0076-6879(71)18006-8
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This means that even if you do have a vitamin B12 deficiency, your body will likely be able to compensate for this at least from a methylation perspective via your dietary choices