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10.1016/j.ogc.2011.05.004 Obstet
In breast cancer cell lines (MCF-7), activation of IGF/PI3K signaling enhances mitochondrial homeostasis by increasing the number of new mitochondria and levels of oxidative phosphorylation and promotes the degradation of damaged mitochondria (mitochondrial autophagy) by increasing BNIP3, a protective mechanism that ultimately influences the cancer treatment response and evolution of the cancer phenotype (53)
Kurosawa, K., Hayashi, N., Sato, N., Kamada, T
