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Moreover, a multicentric, double-blind, placebo-controlled, randomized trial that used the same methodology found that in patients who are suffering from stage I or II HNSCC and on radiation therapy while taking 400 IU of -tocopherol daily had a significantly higher incidence of subsequent primary malignancies (60/1000 person-years) compared to those on placebo (25/1000 person-years)

The inability to maintain reduced glutathione in RBCs leads to increased accumulation of peroxides, predominantly H 2 O 2 , that in turn results in a weakening of the cell wall as a result of membrane lipid peroxidation resulting in concomitant hemolysis

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The other GST deletion polymorphism, as mentioned, results in GSTT1 null genotype, which might be considered as either risk-associated or protective in certain disorders,(due to its role in detoxification, but also in bioactivation)

Reciprocal regulation of AMP-activated protein kinase and phospholipase D

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