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This is driving force behind heartburn and GERD

10.1046/j.1365-2796.1996.377740000.x 115 SmithE

Safety Position : Neither Eli Lilly nor independent investigators have endorsed higher doses

Tirzepatide, used in medications like Mounjaro and Zepbound, showed even greater results, where participants in some trials lost up to 22.5% of their body weight

161 Over a period of 24 weeks, all dosage groups of retatrutide showed significant improvements in reducing glycated hemoglobin (HbA1c) and body weight compared to the placebo group, especially in the higher dosage groups

However, enzyme supplements may cause their own gastrointestinal side effects that can overlap with GLP-1-related symptoms, and some formulations containing bromelain or papain may interact with anticoagulants