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It refers to the amount of a substance that actually enters your bloodstream and becomes available for your cells to use

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(10) J Svensson, S Lall, S L Dickson, B A Bengtsson, J Rmer, et al (2000) The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats Journal of Endocrinology, 2000 Jun, Volume 165 (Issue 3), Pages 569-77

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Often times, pregnancy is the first time women will notice their spider veins