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For example, a recent clinical trial found that people with stable bipolar disorder who took liraglutide lost weight, lowered A1C (a key diabetes marker), and reduced binge eating

PMID: 11023702

10.1006/bbrc.1998.9489 59 WeyerC.MaggsD

Serious gastrointestinal complications require vigilant monitoring

Dorsomedial hypothalamus GLP-1R are known to be expressed in the neurons of the DMH of mice and humans, and previous studies have emphasized its role in regulating metabolic responses by exendin-4 [68,69]

While this co-formulation certainly improves oral delivery, it hasnt fully solved the problem of dosage requirements