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Leucine is not only a precursor for muscle protein synthesis, but is also a regulator of intracellular pathways that are involved in the process of protein synthesis
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Insulin secretion from the islets of Kcnj11 / mice was significantly elevated even at 0.5 mM glucose, and increasing glucose concentrations stimulated insulin secretion to some degree, with maximal response much lower than that of control mice (Figure 1E): a crossover was observed at approximately 12 mM glucose explaining why Kcnj11 / mice are glucose intolerant
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